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    garr-1 putative H/ACA ribonucleoprotein complex subunit 1-like protein [ Caenorhabditis elegans ]

    Gene ID: 176870, updated on 9-Dec-2024

    Summary

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    Official Symbol
    garr-1
    Official Full Name
    putative H/ACA ribonucleoprotein complex subunit 1-like protein
    Primary source
    WormBase:WBGene00022046
    Locus tag
    CELE_Y66H1A.4
    See related
    AllianceGenome:WB:WBGene00022046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable box H/ACA snoRNA binding activity. Predicted to be involved in snoRNA guided rRNA pseudouridine synthesis. Predicted to be located in nucleolus. Predicted to be part of box H/ACA snoRNP complex. Orthologous to human GAR1 (GAR1 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See garr-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_003282.8 (426168..427204)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene 3'-5' exonuclease eri-1 Neighboring gene Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18 Neighboring gene Saposin B-type domain-containing protein Neighboring gene ncRNA Neighboring gene Myosin motor domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subsequent infection differentially affects the proteome of Caenorhabditis elegans by abrogating the intestinal cell proliferation. Udayakumar P, et al. Microb Pathog, 2022 Jan. PMID 34952153
    2. Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins. Aftab MN, et al. BMC Genomics, 2008 Jun 11. PMID 18547420, Free PMC Article
    3. RG/RGG repeats in the C. elegans homologs of Nucleolin and GAR1 contribute to sub-nucleolar phase separation. Spaulding EL, et al. Nat Commun, 2022 Nov 3. PMID 36329008, Free PMC Article
    4. Box C/D small nucleolar ribonucleoproteins regulate mitochondrial surveillance and innate immunity. Tjahjono E, et al. PLoS Genet, 2022 Mar. PMID 35275914, Free PMC Article
    5. Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. van Haaften G, et al. Curr Biol, 2006 Jul 11. PMID 16824923

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables box H/ACA snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snoRNA guided rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative H/ACA ribonucleoprotein complex subunit 1-like protein
    NP_499927.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      426168..427204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067526.4 → NP_499927.2  putative H/ACA ribonucleoprotein complex subunit 1-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499927.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TYK1
      Conserved Domains (1) summary
      pfam04410
      Location:52 → 148
      Gar1; Gar1/Naf1 RNA binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TYK1.2

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