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    smz-1 PDZ domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smz-1
    Official Full Name
    PDZ domain-containing protein
    Primary source
    WormBase:WBGene00007733
    Locus tag
    CELE_C25G4.6
    See related
    AllianceGenome:WB:WBGene00007733
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in male meiosis chromosome segregation. Located in chromatin. Is expressed in male gonad and sperm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smz-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (12455050..12456299)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ribosome-binding factor A Neighboring gene Condensin complex subunit dpy-26 Neighboring gene Transcription regulator spe-44 Neighboring gene Uncharacterized protein Neighboring gene BTB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement for the ERI/DICER complex in endogenous RNA interference and sperm development in Caenorhabditis elegans. Pavelec DM, et al. Genetics, 2009 Dec. PMID 19797044, Free PMC Article
    2. A specificity map for the PDZ domain family. Tonikian R, et al. PLoS Biol, 2008 Sep 30. PMID 18828675, Free PMC Article
    3. NHR-23 and SPE-44 regulate distinct sets of genes during Caenorhabditis elegans spermatogenesis. Ragle JM, et al. G3 (Bethesda), 2022 Nov 4. PMID 36135804, Free PMC Article
    4. The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures. Franziscus CA, et al. FEBS Open Bio, 2024 Mar. PMID 38320757, Free PMC Article
    5. Sperm chromatin proteomics identifies evolutionarily conserved fertility factors. Chu DS, et al. Nature, 2006 Sep 7. PMID 16943775, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in male meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PDZ domain-containing protein
    NP_502380.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12455050..12456299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069979.8 → NP_502380.1  PDZ domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502380.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18167
      Conserved Domains (2) summary
      cd00992
      Location:114 → 188
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl00117
      Location:7 → 77
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    Nucleotide Protein
    Heading Accession and Version

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