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    vab-7 Homeobox protein vab-7 [ Caenorhabditis elegans ]

    Gene ID: 176521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vab-7
    Official Full Name
    Homeobox protein vab-7
    Primary source
    WormBase:WBGene00006873
    Locus tag
    CELE_M142.4
    See related
    AllianceGenome:WB:WBGene00006873
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate specification and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including Caap; Capp; neurons; somatic nervous system; and tail hypodermis. Orthologous to human EVX1 (even-skipped homeobox 1) and EVX2 (even-skipped homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vab-7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (10920344..10926041)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene GMP phosphodiesterase delta subunit domain-containing protein;Protein unc-119 Neighboring gene Cuticlin-6 Neighboring gene pseudo Neighboring gene AD domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The nematode even-skipped homolog vab-7 regulates gonad and vulva position in Pristionchus pacificus. Jungblut B, et al. Development, 2001 Jan. PMID 11124120
    2. The C. elegans even-skipped homologue, vab-7, specifies DB motoneurone identity and axon trajectory. Esmaeili B, et al. Development, 2002 Feb. PMID 11861469
    3. Proprioceptive coupling within motor neurons drives C. elegans forward locomotion. Wen Q, et al. Neuron, 2012 Nov 21. PMID 23177960, Free PMC Article
    4. Posterior patterning by the Caenorhabditis elegans even-skipped homolog vab-7. Ahringer J. Genes Dev, 1996 May 1. PMID 8654927
    5. An Organ-Specific Differentiation Gene, pha-1, from Caenorhabditis elegans. Schnabel H, et al. Science, 1990 Nov 2. PMID 17810870

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox protein vab-7
    NP_499401.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10920344..10926041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067000.6 → NP_499401.1  Homeobox protein vab-7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499401.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23093, Q93899
      Conserved Domains (1) summary
      pfam00046
      Location:72 → 124
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93899.2

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