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    mrp-8 Multidrug resistance-associated protein 1 [ Caenorhabditis elegans ]

    Gene ID: 190710, updated on 9-Dec-2024

    Summary

    Official Symbol
    mrp-8
    Official Full Name
    Multidrug resistance-associated protein 1
    Primary source
    WormBase:WBGene00003414
    Locus tag
    CELE_Y75B8A.26
    See related
    AllianceGenome:WB:WBGene00003414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in arterial calcification of infancy; coronary artery disease; and pseudoxanthoma elasticum. Orthologous to human ABCC6 (ATP binding cassette subfamily C member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See mrp-8 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    21
    Sequence:
    Chromosome: III; NC_003281.10 (12283133..12303184, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene 1-phosphatidylinositol 4-kinase Neighboring gene RanBD1 domain-containing protein Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Coiled-coil domain-containing protein 73

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATPase-coupled transmembrane transporter activity  
    Process Evidence Code Pubs
    involved_in transmembrane transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    is_active_in membrane  
    located_in membrane  

    General protein information

    Preferred Names
    Multidrug resistance-associated protein 1
    NP_499598.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12283133..12303184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067197.5NP_499598.2  Multidrug resistance-associated protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499598.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XW61
      Conserved Domains (4) summary
      cd03244
      Location:12191439
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:568770
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:1731459
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:259527
      ABC_membrane; ABC transporter transmembrane region
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