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    moma-1 MICOS complex subunit MIC27 [ Caenorhabditis elegans ]

    Gene ID: 175243, updated on 9-Dec-2024

    Summary

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    Official Symbol
    moma-1
    Official Full Name
    MICOS complex subunit MIC27
    Primary source
    WormBase:WBGene00019333
    Locus tag
    CELE_K02F3.10
    See related
    AllianceGenome:WB:WBGene00019333
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in cristae formation. Located in mitochondrial outer membrane. Orthologous to several human genes including APOOL (apolipoprotein O like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See moma-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (851331..852396, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF148 domain-containing protein Neighboring gene Fatty Acid/Retinol binding protein Neighboring gene putative calcium-binding mitochondrial carrier K02F3.2 Neighboring gene RRM domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. Head BP, et al. Mol Biol Cell, 2011 Mar 15. PMID 21248201, Free PMC Article
    2. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
    3. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    4. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that MOMA-1 is involved with mitochondrial cristae morphology in C. elegans.
      Title: A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MICOS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MICOS complex subunit MIC27
    NP_497275.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      851331..852396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064874.6 → NP_497275.1  MICOS complex subunit MIC27 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497275.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21154
      Conserved Domains (1) summary
      pfam09769
      Location:64 → 165
      ApoO; Apolipoprotein O
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21154.1

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