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    cpl-1 Cathepsin L-like [ Caenorhabditis elegans ]

    Gene ID: 180111, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpl-1
    Official Full Name
    Cathepsin L-like
    Primary source
    WormBase:WBGene00000776
    Locus tag
    CELE_T03E6.7
    See related
    AllianceGenome:WB:WBGene00000776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including lipid droplet disassembly; positive regulation of vitellogenesis; and regulation of apoptosis involved in tissue homeostasis. Located in several cellular components, including lysosome; vesicle lumen; and yolk granule. Is expressed in several structures, including cuticle; eggshell; hermaphrodite gonad; pharynx; and vulva. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSL (cathepsin L). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpl-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (16592572..16595346, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA Neighboring gene tRNA-Gln Neighboring gene Serpentine Receptor, class H Neighboring gene Serpentine Receptor, class H

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and purification of an active cysteine protease of Haemonchus contortus using Caenorhabditis elegans. Murray L, et al. Int J Parasitol, 2007 Aug. PMID 17451718
    2. A cathepsin L-like protease from Strongylus vulgaris: an orthologue of Caenorhabditis elegans CPL-1. Ultaigh SN, et al. Exp Parasitol, 2009 Apr. PMID 19059238
    3. Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans. Hashmi S, et al. J Biol Chem, 2002 Feb 1. PMID 11707440
    4. A cathepsin L protease essential for Caenorhabditis elegans embryogenesis is functionally conserved in parasitic nematodes. Britton C, et al. Mol Biochem Parasitol, 2002 Jun. PMID 12076767
    5. The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans. Xu M, et al. Mol Biol Cell, 2014 Jul 1. PMID 24829385, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study reveals a previously undescribed molecular mechanism by which peripheral CPL-1/cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin signaling.
      Title: Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis.
    2. cpl-1, ccz-1, and asm-3 are genes required for the processing of lipid-containing droplets in C. elegans embryos
      Title: Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos.
    3. CPL-1 is the leading lysosomal protease required for elimination of apoptotic cells in C. elegans.
      Title: The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans.
    4. pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.
      Title: A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.
    5. Cathepsin L protease (CPL-1) has a critical role in yolk processing during embryogenesis in Caenorhabditis elegans
      Title: Cathepsin L protease (CPL-1) is essential for yolk processing during embryogenesis in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid droplet disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of vitellogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptosis involved in tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endolysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagolysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in yolk granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cathepsin L-like
    NP_001256718.1
    • Confirmed by transcript evidence
    NP_001256719.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16592572..16595346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269789.4 → NP_001256718.1  Cathepsin L-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256718.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H9G333, O45734
      Conserved Domains (2) summary
      pfam00112
      Location:120 → 335
      Peptidase_C1; Papain family cysteine protease
      pfam08246
      Location:32 → 91
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    2. NM_001269790.3 → NP_001256719.1  Cathepsin L-like [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256719.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G333
      Conserved Domains (1) summary
      pfam00112
      Location:1 → 196
      Peptidase_C1; Papain family cysteine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O45734.1

    Gene LinkOut

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