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    mlt-10 Molting protein mlt-10 [ Caenorhabditis elegans ]

    Gene ID: 173445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mlt-10
    Official Full Name
    Molting protein mlt-10
    Primary source
    WormBase:WBGene00015646
    Locus tag
    CELE_C09E8.3
    See related
    AllianceGenome:WB:WBGene00015646
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and epidermis development. Located in extracellular space. Is expressed in hypodermal cell and pharyngeal epithelial cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mlt-10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (546705..552032)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neighboring gene F-box associated domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene LIPaSe related;Triacylglycerol lipase Neighboring gene Sodium-and chloride-dependent glycine transporter 2 Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Experimental considerations for study of C. elegans lysosomal proteins. Clancy JC, et al. G3 (Bethesda), 2023 Apr 11. PMID 36748711, Free PMC Article
    2. GRD-1/PTR-11, the C. elegans hedgehog/patched-like morphogen-receptor pair, modulates developmental rate. Emans SW, et al. Development, 2023 Dec 15. PMID 37982457, Free PMC Article
    3. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Hayes GD, et al. Development, 2006 Dec. PMID 17065234
    4. MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Meli VS, et al. Mol Biol Cell, 2010 May 15. PMID 20335506, Free PMC Article
    5. Epidermal PAR-6 and PKC-3 are essential for larval development of C. elegans and organize non-centrosomal microtubules. Castiglioni VG, et al. Elife, 2020 Dec 10. PMID 33300872, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mlt-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.
      Title: MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Molting protein mlt-10
    NP_493755.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      546705..552032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061354.5 → NP_493755.1  Molting protein mlt-10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493755.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76555
      Conserved Domains (1) summary
      pfam04870
      Location:189 → 502
      Moulting_cycle; Moulting cycle
    Nucleotide Protein
    Heading Accession and Version

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