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    fbxa-60 F-box domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 188448, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fbxa-60
    Official Full Name
    F-box domain-containing protein
    Primary source
    WormBase:WBGene00020456
    Locus tag
    CELE_T12B5.10
    See related
    AllianceGenome:WB:WBGene00020456
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in innate immune response. Acts upstream of or within PERK-mediated unfolded protein response. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fbxa-60 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (944733..946300, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DUF38 domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene F-box domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    2. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    3. The F-box protein family. Kipreos ET, et al. Genome Biol, 2000. PMID 11178263, Free PMC Article
    4. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    5. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    acts_upstream_of_or_within PERK-mediated unfolded protein response HEP PubMed 
    involved_in innate immune response HEP PubMed 

    General protein information

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    Preferred Names
    F-box domain-containing protein
    NP_497300.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      944733..946300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064899.4 → NP_497300.1  F-box domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497300.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZ26
      Conserved Domains (2) summary
      smart00256
      Location:59 → 98
      FBOX; A Receptor for Ubiquitination Targets
      pfam01827
      Location:173 → 314
      FTH; FTH domain
    Nucleotide Protein
    Heading Accession and Version

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