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    mtl-1 Metallothionein-1 [ Caenorhabditis elegans ]

    Gene ID: 179060, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mtl-1
    Official Full Name
    Metallothionein-1
    Primary source
    WormBase:WBGene00003473
    Locus tag
    CELE_K11G9.6
    See related
    AllianceGenome:WB:WBGene00003473
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cadmium ion binding activity and zinc ion binding activity. Involved in several processes, including response to cadmium ion; response to lead ion; and response to mercury ion. Predicted to be located in cytoplasm. Is expressed in intestine and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mtl-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (6691371..6691863, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene Metallothionein Neighboring gene Alkaline ceramidase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nutritive Manganese and Zinc Overdosing in Aging C. elegans Result in a Metallothionein-Mediated Alteration in Metal Homeostasis. Baesler J, et al. Mol Nutr Food Res, 2021 Apr. PMID 33641237, Free PMC Article
    2. Caenorhabditis elegans metallothioneins protect against toxicity induced by depleted uranium. Jiang GC, et al. Toxicol Sci, 2009 Oct. PMID 19617453
    3. Nematode and snail metallothioneins. Höckner M, et al. J Biol Inorg Chem, 2011 Oct. PMID 21822727
    4. Trans-generational effects of copper on nerve damage in Caenorhabditis elegans. Zhang Y, et al. Chemosphere, 2021 Dec. PMID 34225113
    5. Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes. Ye B, et al. PLoS One, 2010 Nov 18. PMID 21124968, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the defects of adaptive response to neurobehavioral toxicity induced by metal exposure formed in mtl-1 and mtl-2 mutants could be completely rescued by the expression of mtl-1 and mtl-2 with the aid of their native promoters.
      Title: Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes.
    2. Caenorhabditis elegans metallothionein isoform specificity--metal binding abilities and the role of histidine in CeMT1
      Title: Caenorhabditis elegans metallothionein isoform specificity--metal binding abilities and the role of histidine in CeMT1 and CeMT2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cadmium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cadmium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables copper ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to metal ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to lead ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to mercury ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Metallothionein-1
    NP_504696.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6691371..6691863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072295.6 → NP_504696.1  Metallothionein-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504696.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P17511
      Conserved Domains (1) summary
      pfam12785
      Location:3 → 66
      VESA1_N; Variant erythrocyte surface antigen-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17511.2

    Gene LinkOut

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