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    his-2 Histone H3 [ Caenorhabditis elegans ]

    Gene ID: 180074, updated on 9-Dec-2024

    Summary

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    Official Symbol
    his-2
    Official Full Name
    Histone H3
    Primary source
    WormBase:WBGene00001876
    Locus tag
    CELE_T10C6.13
    See related
    AllianceGenome:WB:WBGene00001876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables methylated histone binding activity. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome. Is expressed in reproductive system. Orthologous to several human genes including H3C1 (H3 clustered histone 1); H3C10 (H3 clustered histone 10); and H3C11 (H3 clustered histone 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See his-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_003283.11 (16041873..16042283, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Histone H2B 2 Neighboring gene ncRNA Neighboring gene Histone H2A Neighboring gene Histone H4 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24. Studencka M, et al. PLoS Genet, 2012 Sep. PMID 23028351, Free PMC Article
    2. Replication-coupled chromatin assembly generates a neuronal bilateral asymmetry in C. elegans. Nakano S, et al. Cell, 2011 Dec 23. PMID 22177093, Free PMC Article
    3. Nucleotide sequences of Caenorhabditis elegans core histone genes. Genes for different histone classes share common flanking sequence elements. Roberts SB, et al. J Mol Biol, 1989 Apr 20. PMID 2544730
    4. HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity. Sural S, et al. Sci Adv, 2020 Oct. PMID 33087356, Free PMC Article
    5. The Caenorhabditis elegans histone hairpin-binding protein is required for core histone gene expression and is essential for embryonic and postembryonic cell division. Pettitt J, et al. J Cell Sci, 2002 Feb 15. PMID 11865041

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage.
      Title: H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Histone H3
    NP_507033.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      16041873..16042283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074632.5 → NP_507033.1  Histone H3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507033.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08898, Q9TW44
      UniProtKB/TrEMBL
      K7ZUH9
      Conserved Domains (1) summary
      PTZ00018
      Location:1 → 136
      PTZ00018; histone H3; Provisional
    Nucleotide Protein
    Heading Accession and Version

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