brc-1 Breast cancer type 1 susceptibility protein homolog;RING-type E3 ubiquitin transferase BRCA1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: brc-1
Official Full Name: Breast cancer type 1 susceptibility protein homolog;RING-type E3 ubiquitin transferase BRCA1
Primary source: WormBase:WBGene00000264
Locus tag: CELE_C36A4.8
See related: AllianceGenome:WB:WBGene00000264
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin protein ligase activity. Involved in several processes, including DNA repair; cellular response to ionizing radiation; and nuclear chromosome segregation. Part of BRCA1-BARD1 complex. Is expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia complementation group S; breast cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See brc-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (3853102..3862968, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conservation of transcriptional regulation by BRCA1 and BARD1 in Caenorhabditis elegans.
Title: Conservation of transcriptional regulation by BRCA1 and BARD1 in Caenorhabditis elegans.
PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.
Title: PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.
Meiotic Double-Strand Break Processing and Crossover Patterning Are Regulated in a Sex-Specific Manner by BRCA1-BARD1 in Caenorhabditis elegans.
Title: Meiotic Double-Strand Break Processing and Crossover Patterning Are Regulated in a Sex-Specific Manner by BRCA1-BARD1 in Caenorhabditis elegans.
BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining.
Title: BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining.
the C. elegans homologs of the BRCA1/BARD1 tumor suppressor genes, brc-1/brd-1, were identified as mediators of the anti-apoptotic effect but dispensable for lifespan extension upon mitochondrial stress.
Title: BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans.
Data suggest that BRC-1/BRD-1 can both promote and antagonize genome stability depending on whether homologous recombination is initiated during DNA double-strand break repair or during replication stalling.
Title: Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants.
BRAP-2 is necessary for preventing an inappropriate response to elevated levels of reactive oxygen species by countering premature activation of BRC-1 and CKI-1.
Title: Developmental arrest of Caenorhabditis elegans BRAP-2 mutant exposed to oxidative stress is dependent on BRC-1.
brc-1 mutants show an abnormal increase in apoptosis and RAD-51 foci at pachytene that are abolished by loss of spo-11 function, suggesting a defect in meiosis rather than during premeiotic DNA replication.
Title: BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair.
Ce-BRC-1 and Ce-BRD-1 share a role in C. elegans DNA repair processes.
Title: BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-132 (e-PCR)
- UniSTS:241972

C36A4.8 (e-PCR)
- UniSTS:307310

C36A4.7 (e-PCR)
- UniSTS:312517

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleotide-excision repair	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleotide-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of BRCA1-BARD1 complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Breast cancer type 1 susceptibility protein homolog;RING-type E3 ubiquitin transferase BRCA1

NP_001254882.1

Confirmed by transcript evidence

NP_001367205.1

Confirmed by transcript evidence

NP_001417850.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

3853102..3862968 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001430933.1 → NP_001417850.1 RING-type E3 ubiquitin transferase BRCA1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

B6VQ60, B6VQ61

UniProtKB/TrEMBL

A0A679L8N4
NM_001381810.2 → NP_001367205.1 Breast cancer type 1 susceptibility protein homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

B6VQ60, B6VQ61

Conserved Domains (2) summary

cl00038
Location:505 → 598

BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains

cl17238
Location:18 → 61

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001267953.3 → NP_001254882.1 Breast cancer type 1 susceptibility protein homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254882.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B6VQ60

Conserved Domains (1) summary

smart00292
Location:13 → 95

BRCT; breast cancer carboxy-terminal domain