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    dpy-11 Thioredoxin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179040, updated on 9-Dec-2024

    Summary

    Official Symbol
    dpy-11
    Official Full Name
    Thioredoxin domain-containing protein
    Primary source
    WormBase:WBGene00001073
    Locus tag
    CELE_F46E10.9
    See related
    AllianceGenome:WB:WBGene00001073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein-disulfide reductase activity. Involved in several processes, including cuticle development involved in collagen and cuticulin-based cuticle molting cycle; post-embryonic body morphogenesis; and protein folding. Located in endomembrane system. Is expressed in several structures, including R1_hyp; R2_hyp; R3_hyp; R4_hyp; and R5_hyp. Orthologous to several human genes including TMX1 (thioredoxin related transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See dpy-11 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (6511585..6513346, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene Ubiquitin carboxyl-terminal hydrolase Neighboring gene ncRNA Neighboring gene Malate dehydrogenase, cytoplasmic

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    Thioredoxin domain-containing protein
    NP_001370731.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6511585..6513346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383321.2NP_001370731.1  Thioredoxin domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC91
      Conserved Domains (1) summary
      cd02994
      Location:24124
      PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...