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    lst-2 Lateral signaling target protein 2 [ Caenorhabditis elegans ]

    Gene ID: 180712, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lst-2
    Official Full Name
    Lateral signaling target protein 2
    Primary source
    WormBase:WBGene00003084
    Locus tag
    CELE_R160.7
    See related
    AllianceGenome:WB:WBGene00003084
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in negative regulation of epidermal growth factor receptor signaling pathway. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lst-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (4378004..4383366, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DUF4492 domain-containing protein Neighboring gene Methyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AP-2 complex subunit mu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. Mosesson Y, et al. Dev Cell, 2009 May. PMID 19460345, Free PMC Article
    2. Executing multicellular differentiation: quantitative predictive modelling of C.elegans vulval development. Bonzanni N, et al. Bioinformatics, 2009 Aug 15. PMID 19515963
    3. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Hayakawa A, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16873553, Free PMC Article
    4. Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Yoo AS, et al. Science, 2004 Jan 30. PMID 14752159
    5. RTK/Ras/MAPK signaling. Sundaram MV. WormBook, 2006 Feb 11. PMID 18050474, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Lateral signaling target protein 2
    NP_508756.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4378004..4383366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076355.6 → NP_508756.2  Lateral signaling target protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508756.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TZD0
      Conserved Domains (2) summary
      cd15731
      Location:559 → 623
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins
      pfam05285
      Location:361 → 453
      SDA1; SDA1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TZD0.2

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