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    kcnl-2 Calmodulin-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172602, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kcnl-2
    Official Full Name
    Calmodulin-binding domain-containing protein
    Primary source
    WormBase:WBGene00008570
    Locus tag
    CELE_F08A10.1
    See related
    AllianceGenome:WB:WBGene00008570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calmodulin binding activity and small conductance calcium-activated potassium channel activity. Involved in positive regulation of egg-laying behavior. Located in neuron projection. Is expressed in nervous system; seam cell; and vulval muscle. Human ortholog(s) of this gene implicated in myoclonic dystonia 34; paranoid schizophrenia; and schizophrenia. Orthologous to several human genes including KCNN1 (potassium calcium-activated channel subfamily N member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kcnl-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    26
    Sequence:
    Chromosome: I; NC_003279.8 (8174888..8208742)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Proteasome activator complex subunit 4 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Serpentine Receptor, class Z Neighboring gene Uncharacterized protein Neighboring gene Transmembrane protein Neighboring gene Protein dhs-3 Neighboring gene C3H1-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A V-to-F substitution in SK2 channels causes Ca(2+) hypersensitivity and improves locomotion in a C. elegans ALS model. Nam YW, et al. Sci Rep, 2018 Jul 16. PMID 30013223, Free PMC Article
    2. A small conductance calcium-activated K+ channel in C. elegans, KCNL-2, plays a role in the regulation of the rate of egg-laying. Chotoo CK, et al. PLoS One, 2013. PMID 24040423, Free PMC Article
    3. The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1. Srivastava S, et al. Mol Cell Biol, 2005 May. PMID 15831468, Free PMC Article
    4. Neural circuits for sexually dimorphic and sexually divergent behaviors in Caenorhabditis elegans. García LR, et al. Curr Opin Neurobiol, 2016 Jun. PMID 26929998, Free PMC Article
    5. Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans. Gaeta AL, et al. PLoS Genet, 2022 Aug. PMID 35984862, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study found that the substitution of a valine to phenylalanine (V407F) in the intrinsically disordered fragment of C. elegans KCNL-2 protein (human SK2 orthologue) partially rescues locomotion defects in a model of SOD1-associated amyotrophic lateral sclerosis. This result suggests that the valine to phenylalanine substitution increases Ca2+ sensitivity of small-conductance Ca2+-activated K+ channels in vivo.
      Title: A V-to-F substitution in SK2 channels causes Ca(2+) hypersensitivity and improves locomotion in a C. elegans ALS model.
    2. findings the vulva of transgenic hermaphrodites is highly innervated by neuronal processes and by the VC4 and VC5 neurons that express GFP-tagged KCNL-2; propose that KCNL-2 functions in the nervous system of C. elegans to regulate the rate of egg-laying
      Title: A small conductance calcium-activated K+ channel in C. elegans, KCNL-2, plays a role in the regulation of the rate of egg-laying.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small conductance calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small conductance calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small conductance calcium-activated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Calmodulin-binding domain-containing protein
    NP_001021087.1
    • Confirmed by transcript evidence
    NP_001122445.1
    • Partially confirmed by transcript evidence
    NP_001250694.1
    • Confirmed by transcript evidence
    NP_001293203.1
    • Confirmed by transcript evidence
    NP_001293204.1
    • Confirmed by transcript evidence
    NP_001293205.1
    • Partially confirmed by transcript evidence
    NP_001359768.1
    • Confirmed by transcript evidence
    NP_492234.2
    • Confirmed by transcript evidence
    NP_871791.1
    • Confirmed by transcript evidence
    NP_871792.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8174888..8208742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306275.3 → NP_001293204.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293204.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLK4
      Conserved Domains (3) summary
      smart01053
      Location:704 → 779
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:414 → 524
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:608 → 690
      Ion_trans_2; Ion channel

    2. NM_001373153.1 → NP_001359768.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBM2, G5ECM0
      Conserved Domains (3) summary
      smart01053
      Location:534 → 609
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:247 → 355
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:438 → 520
      Ion_trans_2; Ion channel

    3. NM_001306276.3 → NP_001293205.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293205.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECM0, V6CLJ1
      Conserved Domains (3) summary
      smart01053
      Location:563 → 638
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:273 → 383
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:467 → 549
      Ion_trans_2; Ion channel

    4. NM_001263765.3 → NP_001250694.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250694.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECM0, G5EDA9
      Conserved Domains (3) summary
      smart01053
      Location:501 → 576
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:214 → 322
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:405 → 487
      Ion_trans_2; Ion channel

    5. NM_059833.7 → NP_492234.2  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492234.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECM0, G5EGU5
      Conserved Domains (3) summary
      smart01053
      Location:501 → 576
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:214 → 322
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:405 → 487
      Ion_trans_2; Ion channel

    6. NM_001306274.3 → NP_001293203.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECM0, K7STE9
      Conserved Domains (3) summary
      smart01053
      Location:501 → 576
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:214 → 322
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:405 → 487
      Ion_trans_2; Ion channel

    7. NM_001128973.3 → NP_001122445.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122445.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECI3, G5ECM0
      Conserved Domains (3) summary
      smart01053
      Location:535 → 610
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:248 → 356
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:439 → 521
      Ion_trans_2; Ion channel

    8. NM_001025916.5 → NP_001021087.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021087.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECM0, G5EEU0
      Conserved Domains (3) summary
      smart01053
      Location:494 → 569
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:207 → 315
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:398 → 480
      Ion_trans_2; Ion channel

    9. NM_181992.7 → NP_871792.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871792.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4G4
      Conserved Domains (3) summary
      smart01053
      Location:521 → 596
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:234 → 342
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:425 → 507
      Ion_trans_2; Ion channel

    10. NM_181991.5 → NP_871791.1  Calmodulin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871791.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I4G5
      Conserved Domains (3) summary
      smart01053
      Location:521 → 596
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:234 → 342
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:425 → 507
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version

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