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    chpf-1 EF-hand domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179415, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chpf-1
    Official Full Name
    EF-hand domain-containing protein
    Primary source
    WormBase:WBGene00014109
    Locus tag
    CELE_ZK856.8
    See related
    AllianceGenome:WB:WBGene00014109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in protein transport. Predicted to be located in cytoplasm and nucleus. Predicted to be active in plasma membrane. Is expressed in head; intestine; muscle cell; tail; and in male. Human ortholog(s) of this gene implicated in spastic ataxia. Orthologous to several human genes including CHP1 (calcineurin like EF-hand protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chpf-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (10202538..10203485, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Metallophos domain-containing protein Neighboring gene NGF domain-containing protein Neighboring gene Secreted protein Neighboring gene putative RNA-binding protein EIF1AD Neighboring gene Uncharacterized protein Neighboring gene Ovule protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand domain-containing protein
    NP_001379127.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10202538..10203485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392590.1 → NP_001379127.1  EF-hand domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23643
      Conserved Domains (1) summary
      COG5126
      Location:14 → 182
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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