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    dct-17 CUB-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dct-17
    Official Full Name
    CUB-like domain-containing protein
    Primary source
    WormBase:WBGene00009431
    Locus tag
    CELE_F35E12.7
    See related
    AllianceGenome:WB:WBGene00009431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in defense response to Gram-negative bacterium and innate immune response. Located in membrane raft. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dct-17 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    12
    Sequence:
    Chromosome: V; NC_003283.11 (13727761..13730784, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CUB-like domain-containing protein;CUB_2 domain-containing protein Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. Anderson EN, et al. Mech Ageing Dev, 2016 Mar. PMID 26854551, Free PMC Article
    2. RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response. Zhang T, et al. PLoS Genet, 2014 Oct. PMID 25329970, Free PMC Article
    3. daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival. Hibshman JD, et al. Elife, 2017 Oct 24. PMID 29063832, Free PMC Article
    4. Monascin from Monascus-Fermented Products Reduces Oxidative Stress and Amyloid-β Toxicity via DAF-16/FOXO in Caenorhabditis elegans. Shi YC, et al. J Agric Food Chem, 2016 Sep 28. PMID 27554775
    5. Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity. Nandakumar M, et al. PLoS Genet, 2008 Nov. PMID 19023415, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This work demonstrates that daf-16/FoxO promotes starvation resistance by shifting carbon metabolism to drive trehalose synthesis, which in turn supports survival by providing an energy source and acting as a stress protectant.
      Title: daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival.
    2. mRNA levels of transgenic strains CL4176 of Caenorhabditis elegans of several antioxidant genes (sod-1, sod-2, sod-3, hsp16.2) and daf-16 were up-regulated by monascin treatment when compared to the nontreated controls.
      Title: Monascin from Monascus-Fermented Products Reduces Oxidative Stress and Amyloid-β Toxicity via DAF-16/FOXO in Caenorhabditis elegans.
    3. FUdR-induced hypertonic stress resistance was partially dependent on sirtuins and base excision repair (BER) pathways, while FUdR-induced lifespan extension under hypertonic stress conditions requires DAF-16, BER, and sirtuin function.
      Title: C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.
    4. TDP-1 regulates lifespan and proteotoxicity through DAF-16.
      Title: RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response HEP PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane raft HDA PubMed 

    General protein information

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    Preferred Names
    CUB-like domain-containing protein
    NP_001023877.1
    • Partially confirmed by transcript evidence
    NP_001023878.1
    • Confirmed by transcript evidence
    NP_001023879.1
    • Confirmed by transcript evidence
    NP_001023880.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13727761..13730784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028708.6 → NP_001023879.1  CUB-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023879.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q52GY1
      Conserved Domains (1) summary
      pfam02408
      Location:23 → 132
      CUB_2; CUB-like domain

    2. NM_001028707.6 → NP_001023878.1  CUB-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023878.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q52GX8
      Conserved Domains (1) summary
      pfam02408
      Location:23 → 132
      CUB_2; CUB-like domain

    3. NM_001028709.5 → NP_001023880.1  CUB-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023880.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q52GY0
      Conserved Domains (2) summary
      PHA03255
      Location:473 → 566
      PHA03255; BDLF3; Provisional
      cl00049
      Location:23 → 132
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    4. NM_001028706.7 → NP_001023877.1  CUB-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023877.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02360
      Conserved Domains (2) summary
      pfam05109
      Location:470 → 710
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl00049
      Location:23 → 132
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    Nucleotide Protein
    Heading Accession and Version

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