mek-1 Dual specificity mitogen-activated protein kinase kinase mek-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mek-1
Official Full Name: Dual specificity mitogen-activated protein kinase kinase mek-1
Primary source: WormBase:WBGene00003185
Locus tag: CELE_K08A8.1
See related: AllianceGenome:WB:WBGene00003185
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables JUN kinase kinase activity and SH2 domain binding activity. Involved in several processes, including MAPK cascade; determination of adult lifespan; and positive regulation of axon extension involved in regeneration. Predicted to be located in cytoplasm. Is expressed in several structures, including ganglia; hermaphrodite gonad; intestine; nerve ring; and pharynx. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; lung carcinoma; and lung non-small cell carcinoma. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mek-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 4

Sequence:: Chromosome: X; NC_003284.9 (7479248..7481005)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SHC-1 acts as a scaffold to link MAPKKK to MAPKK activation in the KGB-1 MAPK signal transduction pathway.
Title: Role of the Caenorhabditis elegans Shc adaptor protein in the c-Jun N-terminal kinase signaling pathway.
oxidative, osmotic, heat shock and starvation stresses induce germ cell apoptosis through a p53 and EGL-1 independent pathway; the MAPK kinases MEK-1 and SEK-1, and the p53 antagonist protein ABL-1, are essential for stress-induced germ cell apoptosis
Title: Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K08A8.1 (e-PCR)
- UniSTS:312406

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension involved in regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of growth rate	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cadmium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to copper ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stress	IEA Inferred from Electronic Annotation more info
involved_in response to temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress response to copper ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: Dual specificity mitogen-activated protein kinase kinase mek-1

NP_001024771.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7479248..7481005

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029600.7 → NP_001024771.1 Dual specificity mitogen-activated protein kinase kinase mek-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024771.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21307, Q7Z1P1

Conserved Domains (2) summary

smart00220
Location:73 → 325

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06618
Location:56 → 345

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7