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    Y66D12A.7 Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 176590, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y66D12A.7
    Official Full Name
    Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
    Primary source
    WormBase:WBGene00013433
    Locus tag
    CELE_Y66D12A.7
    See related
    AllianceGenome:WB:WBGene00013433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Predicted to be involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Predicted to be part of glutamyl-tRNA(Gln) amidotransferase complex. Predicted to be active in mitochondrion. Is expressed in hypodermis and tail. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 42. Orthologous to human GATC (glutamyl-tRNA amidotransferase subunit C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y66D12A.7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003281.10 (11579234..11580478, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Proteasome activator PA28 C-terminal domain-containing protein;Proteasome activator complex subunit 3 Neighboring gene STING ER exit protein Neighboring gene Uncharacterized protein Neighboring gene Homeobox-cysteine loop-homeobox domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glutamyl-tRNA(Gln) amidotransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
    NP_499495.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11579234..11580478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067094.7 → NP_499495.1  Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499495.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9BI40
      Conserved Domains (1) summary
      PRK00034
      Location:46 → 134
      gatC; aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BI40.1

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