gras-1 General receptor for phosphoinositides 1-associated scaffold protein 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gras-1
Official Full Name: General receptor for phosphoinositides 1-associated scaffold protein 1 homolog
Primary source: WormBase:WBGene00009272
Locus tag: CELE_F30F8.3
See related: AllianceGenome:WB:WBGene00009272
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in meiotic cell cycle. Predicted to be located in nucleus; perinuclear region of cytoplasm; and plasma membrane. Is expressed in oocyte. Orthologous to human CYTIP (cytohesin 1 interacting protein) and TAMALIN (trafficking regulator and scaffold protein tamalin). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gras-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (7835813..7836967)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans.
Title: GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F30F8.1 (e-PCR)
- UniSTS:310037

F30F8.3 (e-PCR)
- UniSTS:314166

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: General receptor for phosphoinositides 1-associated scaffold protein 1 homolog

NP_492164.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7835813..7836967

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059763.7 → NP_492164.1 General receptor for phosphoinositides 1-associated scaffold protein 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492164.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93654

Conserved Domains (1) summary

cd00136
Location:67 → 145

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...