U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cki-2 Cyclin-dependent kinase inhibitor domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174261, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cki-2
    Official Full Name
    Cyclin-dependent kinase inhibitor domain-containing protein
    Primary source
    WormBase:WBGene00000517
    Locus tag
    CELE_T05A6.2
    See related
    AllianceGenome:WB:WBGene00000517
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in gonad development; regulation of cell cycle process; and regulation of cell division. Predicted to be located in nucleus. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P6.p hermaphrodite; and germ line. Human ortholog(s) of this gene implicated in several diseases, including Beckwith-Wiedemann syndrome; IMAGe syndrome; hematologic cancer (multiple); hyperinsulinism; and multiple endocrine neoplasia type 4. Orthologous to several human genes including CDKN1B (cyclin dependent kinase inhibitor 1B). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cki-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (7816499..7820281)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Receptor L-domain domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. mab-2 encodes RNT-1, a C. elegans Runx homologue essential for controlling cell proliferation in a stem cell-like developmental lineage. Nimmo R, et al. Development, 2005 Nov. PMID 16236764
    2. Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell. Martinez MAQ, et al. Differentiation, 2024 May-Jun. PMID 38522217,
    3. CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. Feng H, et al. Nat Cell Biol, 1999 Dec. PMID 10587644
    4. lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans. Boxem M, et al. Development, 2001 Nov. PMID 11684669
    5. The cyclin-dependent kinase inhibitors, cki-1 and cki-2, act in overlapping but distinct pathways to control cell cycle quiescence during C. elegans development. Buck SH, et al. Cell Cycle, 2009 Aug 15. PMID 19597327, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, the authors report that FBF/Pumilio, a conserved RNA-binding protein, promotes self-renewal of germline stem cells by repressing CKI-2(Cip/Kip), a Cyclin E/Cdk2 inhibitor.
      Title: FBF represses the Cip/Kip cell-cycle inhibitor CKI-2 to promote self-renewal of germline stem cells in C. elegans.
    2. Both cki-1 and cki-2 mediate cell cycle quiescence, but our genetic and phenotypic analyses demonstrate that they act within distinct pathways to exert control over the cell cycle machinery.
      Title: The cyclin-dependent kinase inhibitors, cki-1 and cki-2, act in overlapping but distinct pathways to control cell cycle quiescence during C. elegans development.
    3. This implies that the proper regulation of a cyclin E-Cdk complex by cki-2 is required for the elimination of the centrosome that occurs before or during oogenesis to ensure the assembly of a bipolar spindle in the C. elegans zygote.
      Title: Cell cycle regulators control centrosome elimination during oogenesis in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gonad development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA endoreduplication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle G1/S phase transition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cyclin-dependent kinase inhibitor domain-containing protein
    NP_001022309.1
    • Confirmed by transcript evidence
    NP_001368240.1
    • Confirmed by transcript evidence
    NP_495642.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7816499..7820281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063241.7 → NP_495642.3  Cyclin-dependent kinase inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495642.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22198
      Conserved Domains (1) summary
      pfam02234
      Location:16 → 63
      CDI; Cyclin-dependent kinase inhibitor

    2. NM_001027138.6 → NP_001022309.1  Cyclin-dependent kinase inhibitor domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022309.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEJ2
      Conserved Domains (1) summary
      pfam02234
      Location:16 → 64
      CDI; Cyclin-dependent kinase inhibitor

    3. NM_001381510.2 → NP_001368240.1  Cyclin-dependent kinase inhibitor domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBK8
      Conserved Domains (1) summary
      pfam02234
      Location:17 → 65
      CDI; Cyclin-dependent kinase inhibitor
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.