U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    npp-15 Nuclear pore complex protein 15 [ Caenorhabditis elegans ]

    Gene ID: 176114, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    npp-15
    Official Full Name
    Nuclear pore complex protein 15
    Primary source
    WormBase:WBGene00003801
    Locus tag
    CELE_C29E4.4
    See related
    AllianceGenome:WB:WBGene00003801
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of nuclear pore. Predicted to be involved in poly(A)+ mRNA export from nucleus; protein import into nucleus; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Located in kinetochore and nuclear membrane. Part of nuclear pore. Is expressed in pharynx. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Orthologous to human NUP133 (nucleoporin 133). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See npp-15 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (7929043..7933055)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative protein tag-250 Neighboring gene Spiroplasma plectrovirus-related protein Neighboring gene C2H2-type domain-containing protein Neighboring gene ncRNA Neighboring gene Ran GTPase-activating protein 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. D'Angelo MA, et al. Cell, 2009 Jan 23. PMID 19167330, Free PMC Article
    2. Dissection of the NUP107 nuclear pore subcomplex reveals a novel interaction with spindle assembly checkpoint protein MAD1 in Caenorhabditis elegans. Ródenas E, et al. Mol Biol Cell, 2012 Mar. PMID 22238360, Free PMC Article
    3. Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit of nuclear pore complex size exclusion in vivo. Galy V, et al. Mol Biol Cell, 2003 Dec. PMID 12937276, Free PMC Article
    4. Efficient target-selected mutagenesis in Caenorhabditis elegans: toward a knockout for every gene. Cuppen E, et al. Genome Res, 2007 May. PMID 17416746, Free PMC Article
    5. PP2A-B55(SUR-6) promotes nuclear envelope breakdown in C. elegans embryos. Kapoor S, et al. Cell Rep, 2023 Dec 26. PMID 37995185

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of nuclear pore outer ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Nuclear pore complex protein 15
    NP_498724.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7929043..7933055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066323.7 → NP_498724.4  Nuclear pore complex protein 15 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498724.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34343, Q5WRU8
      Conserved Domains (1) summary
      pfam03177
      Location:759 → 886
      Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34343.4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous