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    rhgf-3 DH domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3564893, updated on 27-Dec-2024

    Summary

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    Official Symbol
    rhgf-3
    Official Full Name
    DH domain-containing protein
    Primary source
    WormBase:WBGene00013682
    Locus tag
    CELE_Y105E8A.25
    See related
    AllianceGenome:WB:WBGene00013682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rhgf-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    24
    Sequence:
    Chromosome: I; NC_003279.8 (14567169..14616523, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Acyl-CoA dehydrogenase Neighboring gene Tropomyosin;Tropomyosin isoforms a/b/d/f;Tropomyosin isoforms c/e Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tension-dependent RHGF-1 recruitment to stress fibers drives robust spermathecal tissue contraction. Avivi Kela S, et al. J Cell Biol, 2023 Feb 6. PMID 36574264, Free PMC Article
    2. Genome sequencing of C. elegans balancer strains reveals previously unappreciated complex genomic rearrangements. Maroilley T, et al. Genome Res, 2023 Jan. PMID 36617680, Free PMC Article
    3. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DH domain-containing protein
    NP_001300404.1
    • Confirmed by transcript evidence
    NP_001300405.1
    • Partially confirmed by transcript evidence
    NP_001300448.1
    • Confirmed by transcript evidence
    NP_001300449.1
    • Confirmed by transcript evidence
    NP_001300450.1
    • Confirmed by transcript evidence
    NP_001300451.1
    • Confirmed by transcript evidence
    NP_001360375.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14567169..14616523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313475.3 → NP_001300404.1  DH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATL6
      Conserved Domains (3) summary
      smart00935
      Location:1391 → 1442
      OmpH; Outer membrane protein (OmpH-like)
      cd00160
      Location:706 → 897
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam17838
      Location:949 → 1065
      PH_16; PH domain

    2. NM_001313476.3 → NP_001300405.1  DH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AQN0
      Conserved Domains (3) summary
      smart00935
      Location:1540 → 1591
      OmpH; Outer membrane protein (OmpH-like)
      cd00160
      Location:852 → 1043
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam17838
      Location:1095 → 1211
      PH_16; PH domain

    3. NM_001373664.2 → NP_001360375.1  DH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWN6
      Conserved Domains (3) summary
      smart00935
      Location:1292 → 1343
      OmpH; Outer membrane protein (OmpH-like)
      cd00160
      Location:607 → 798
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam17838
      Location:850 → 966
      PH_16; PH domain

    4. NM_001313519.3 → NP_001300448.1  DH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARB1
      Conserved Domains (3) summary
      smart00935
      Location:966 → 1017
      OmpH; Outer membrane protein (OmpH-like)
      pfam17838
      Location:524 → 640
      PH_16; PH domain
      cl02571
      Location:281 → 472
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    5. NM_001313522.3 → NP_001300451.1  DH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUB5
      Conserved Domains (3) summary
      smart00935
      Location:892 → 943
      OmpH; Outer membrane protein (OmpH-like)
      pfam17838
      Location:450 → 566
      PH_16; PH domain
      cl02571
      Location:207 → 398
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    6. NM_001313520.3 → NP_001300449.1  DH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATR0
      Conserved Domains (3) summary
      smart00935
      Location:777 → 828
      OmpH; Outer membrane protein (OmpH-like)
      pfam17838
      Location:335 → 451
      PH_16; PH domain
      cl02571
      Location:92 → 283
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    7. NM_001313521.3 → NP_001300450.1  DH domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AQS4
      Conserved Domains (3) summary
      smart00935
      Location:749 → 800
      OmpH; Outer membrane protein (OmpH-like)
      pfam17838
      Location:307 → 423
      PH_16; PH domain
      cl02571
      Location:64 → 255
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    Nucleotide Protein
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