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    spe-10 Palmitoyltransferase spe-10 [ Caenorhabditis elegans ]

    Gene ID: 3565514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spe-10
    Official Full Name
    Palmitoyltransferase spe-10
    Primary source
    WormBase:WBGene00004964
    Locus tag
    CELE_AC3.10
    See related
    AllianceGenome:WB:WBGene00004964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including amoeboid sperm motility; positive regulation of cell size; and pseudopodium organization. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in spermatid. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spe-10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (10384250..10385740)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA Neighboring gene Aminopeptidase;Aminopeptidase-like protein AC3.5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. spe-10 encodes a DHHC-CRD zinc-finger membrane protein required for endoplasmic reticulum/Golgi membrane morphogenesis during Caenorhabditis elegans spermatogenesis. Gleason EJ, et al. Genetics, 2006 Jan. PMID 16143610, Free PMC Article
    2. The spe-10 mutant has longer life and increased stress resistance. Cypser JR, et al. Neurobiol Aging, 1999 Sep-Oct. PMID 10638523
    3. The effects of Microcystis aeruginosa cells lysate containing microcystins on physiological and molecular responses in the nematode Caenorhabditis elegans. Sopezki MS, et al. Environ Toxicol, 2020 May. PMID 31916382
    4. Effects of Microcystin-LR Exposure on Spermiogenesis in Nematode Caenorhabditis elegans. Li Y, et al. Int J Mol Sci, 2015 Sep 22. PMID 26402677, Free PMC Article
    5. Mutations that disrupt the morphogenesis and localization of a sperm-specific organelle in Caenorhabditis elegans. Shakes DC, et al. Dev Biol, 1989 Aug. PMID 2744235

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amoeboid sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organelle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudopodium organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Palmitoyltransferase spe-10
    NP_001021339.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10384250..10385740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026168.5 → NP_001021339.1  Palmitoyltransferase spe-10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5FC64
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 277
      zf-DHHC; DHHC palmitoyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FC64.1

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