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    rsd-2 AF-9 ANC1 homology domain-containing protein;RSD-2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178322, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rsd-2
    Official Full Name
    AF-9 ANC1 homology domain-containing protein;RSD-2 domain-containing protein
    Primary source
    WormBase:WBGene00004681
    Locus tag
    CELE_F52G2.2
    See related
    AllianceGenome:WB:WBGene00004681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in several cellular components, including endoplasmic reticulum; nucleolus; and perinuclear region of cytoplasm. Is expressed in germ cell and intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rsd-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    21
    Sequence:
    Chromosome: IV; NC_003282.8 (13521970..13540265, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Abhydrolase_3 domain-containing protein;Alpha/beta hydrolase fold-3 domain-containing protein Neighboring gene PUM-HD domain-containing protein Neighboring gene m7GpppN-mRNA hydrolase dcap-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RSD-2 N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations. Sakaguchi A, et al. Proc Natl Acad Sci U S A, 2014 Oct 14. PMID 25258416, Free PMC Article
    2. Antiviral RNA silencing initiated in the absence of RDE-4, a double-stranded RNA binding protein, in Caenorhabditis elegans. Guo X, et al. J Virol, 2013 Oct. PMID 23885080, Free PMC Article
    3. The Caenorhabditis elegans rsd-2 and rsd-6 genes are required for chromosome functions during exposure to unfavorable environments. Han W, et al. Genetics, 2008 Apr. PMID 18430922, Free PMC Article
    4. The RDE-10/RDE-11 complex triggers RNAi-induced mRNA degradation by association with target mRNA in C. elegans. Yang H, et al. Genes Dev, 2012 Apr 15. PMID 22508728, Free PMC Article
    5. Functional characterization in Caenorhabditis elegans of transmembrane worm-human orthologs. Henricson A, et al. BMC Genomics, 2004 Nov 8. PMID 15533247, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RSD-2 and RSD-6 promote germ cell immortality at stressful temperatures by maintaining transgenerational epigenetic inheritance of endogenous siRNA populations that promote genome silencing.
      Title: Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations.
    2. The ultimate functions of rsd-2 and rsd-6 in systemic RNA interference are remarkably complex and environmentally responsive.
      Title: The Caenorhabditis elegans rsd-2 and rsd-6 genes are required for chromosome functions during exposure to unfavorable environments.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AF-9 ANC1 homology domain-containing protein;RSD-2 domain-containing protein
    NP_001040952.2
    • Confirmed by transcript evidence
    NP_001040953.1
    • Confirmed by transcript evidence
    NP_001255749.1
    • Confirmed by transcript evidence
    NP_001255750.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13521970..13540265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047487.3 → NP_001040952.2  RSD-2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040952.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUE3
      Conserved Domains (2) summary
      pfam07547
      Location:98 → 178
      RSD-2; RSD-2 N-terminal domain
      pfam16001
      Location:363 → 439
      DUF4775; Domain of unknown function (DUF4775)

    2. NM_001047488.4 → NP_001040953.1  RSD-2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040953.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2EEN1
      Conserved Domains (2) summary
      pfam07547
      Location:91 → 171
      RSD-2; RSD-2 N-terminal domain
      pfam16001
      Location:173 → 249
      DUF4775; Domain of unknown function (DUF4775)

    3. NM_001268820.3 → NP_001255749.1  RSD-2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255749.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6W0
      Conserved Domains (1) summary
      pfam07547
      Location:105 → 185
      RSD-2; RSD-2 N-terminal domain

    4. NM_001268821.3 → NP_001255750.1  AF-9 ANC1 homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3YT78
    Nucleotide Protein
    Heading Accession and Version

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