ndc-80 Kinetochore protein ndc-80 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ndc-80
Official Full Name: Kinetochore protein ndc-80
Primary source: WormBase:WBGene00003576
Locus tag: CELE_W01B6.9
See related: AllianceGenome:WB:WBGene00003576
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein domain specific binding activity. Involved in several processes, including chromosome organization; gonad morphogenesis; and positive regulation of kinetochore assembly. Located in kinetochore. Part of Ndc80 complex. Orthologous to human NDC80 (NDC80 kinetochore complex component). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ndc-80 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (10086137..10088437)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The outer kinetochore components KNL-1 and Ndc80 complex regulate axon and neuronal cell body positioning in the C. elegans nervous system.
Title: The outer kinetochore components KNL-1 and Ndc80 complex regulate axon and neuronal cell body positioning in the C. elegans nervous system.
Ndc80-tail dephosphorylation promotes stabilization of kinetochore-microtubule attachments via the Ska complex.
Title: Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex.
Ndc80 complex bound to microtubules binds more tightly to beta-tubulin.
Title: Structural comparison of the Caenorhabditis elegans and human Ndc80 complexes bound to microtubules reveals distinct binding behavior.
KLP-7 acts through the Ndc80 complex to limit pole number in C. elegans oocyte meiotic spindle assembly.
Title: KLP-7 acts through the Ndc80 complex to limit pole number in C. elegans oocyte meiotic spindle assembly.
kinetochore dynein module inhibited microtubule binding by the Ndc80 complex; kinetochore dynein module directly regulated Ndc80, independently of phosphorylation by Aurora B kinase, and this regulation was required for accurate segregation
Title: Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W01B6.9 (e-PCR)
- UniSTS:308145

W01B6.7 (e-PCR)
- UniSTS:307130

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in attachment of mitotic spindle microtubules to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in attachment of mitotic spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome movement towards spindle pole	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of kinetochore assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mitotic sister chromatid separation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to kinetochore involved in kinetochore assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Ndc80 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ndc80 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Ndc80 complex	IEA Inferred from Electronic Annotation more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Kinetochore protein ndc-80

NP_501830.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10086137..10088437

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069429.5 → NP_501830.1 Kinetochore protein ndc-80 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501830.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17635, Q23107

Conserved Domains (2) summary

COG5185
Location:76 → 469

HEC1; Protein involved in chromosome segregation, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning]

pfam03801
Location:42 → 180

Ndc80_HEC; HEC/Ndc80p family