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    rsa-1 Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1 [ Caenorhabditis elegans ]

    Gene ID: 172886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rsa-1
    Official Full Name
    Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1
    Primary source
    WormBase:WBGene00007710
    Locus tag
    CELE_C25A1.9
    See related
    AllianceGenome:WB:WBGene00007710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein phosphatase 2A binding activity. Involved in embryo development; mitotic spindle assembly; and protein localization to organelle. Located in centrosome. Human ortholog(s) of this gene implicated in spermatogenic failure 36. Orthologous to human PPP2R3C (protein phosphatase 2 regulatory subunit B''gamma). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rsa-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (10185855..10187550)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Proteasome assembly chaperone 3 Neighboring gene isoleucine--tRNA ligase Neighboring gene C-type lectin domain-containing protein 87 Neighboring gene Nucleolar protein dao-5 Neighboring gene AB hydrolase-1 domain-containing protein;Abhydrolase domain-containing protein lid-1 Neighboring gene Large ribosomal subunit protein mL43 Neighboring gene Aryl hydrocarbon receptor nuclear translocator homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppressor mutations identify amino acids in PAA-1/PR65 that facilitate regulatory RSA-1/B″ subunit targeting of PP2A to centrosomes in C. elegans. Lange KI, et al. Biol Open, 2013 Jan 15. PMID 23336080, Free PMC Article
    2. The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix. Wueseke O, et al. Mol Biol Cell, 2014 Oct 1. PMID 25103243, Free PMC Article
    3. Kinetochore Recruitment of the Spindle and Kinetochore-Associated (Ska) Complex Is Regulated by Centrosomal PP2A in Caenorhabditis elegans. Lange KI, et al. Genetics, 2019 Jun. PMID 31018924, Free PMC Article
    4. The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Schlaitz AL, et al. Cell, 2007 Jan 12. PMID 17218259, Free PMC Article
    5. A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Padmanabhan S, et al. Cell, 2009 Mar 6. PMID 19249087, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rsa-1 regulates the kinetochore localization of the Ska complex, with spindle-associated Aurora A acting as a potential mediator.
      Title: Kinetochore Recruitment of the Spindle and Kinetochore-Associated (Ska) Complex Is Regulated by Centrosomal PP2A in Caenorhabditis elegans.
    2. The RSA complex regulates a subset of PP2A functions at the centrosome. Components of the RSA complex, RSA-1 and RSA-2 and are specifically required for microtubule outgrowth from centrosomes and for spindle assembly.
      Title: The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase 2A binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cortical cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of B cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to organelle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1
    NP_001122424.1
    • Confirmed by transcript evidence
    NP_492683.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10185855..10187550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060282.7 → NP_492683.1  Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492683.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5Z2U4, O02217

    2. NM_001128952.4 → NP_001122424.1  Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122424.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02217
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02217.2

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