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    mnr-1 Menorin [ Caenorhabditis elegans ]

    Gene ID: 180350, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mnr-1
    Official Full Name
    Menorin
    Primary source
    WormBase:WBGene00012184
    Locus tag
    CELE_W01F3.1
    See related
    AllianceGenome:WB:WBGene00012184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in neuron development and regulation of cell morphogenesis. Located in extracellular space and plasma membrane. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including FAM151B (family with sequence similarity 151 member B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mnr-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (20654650..20659744)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein;G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Papilin Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis. Dong X, et al. Cell, 2013 Oct 10. PMID 24120131, Free PMC Article
    2. Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans. Salzberg Y, et al. Cell, 2013 Oct 10. PMID 24120132, Free PMC Article
    3. The proprotein convertase KPC-1/furin controls branching and self-avoidance of sensory dendrites in Caenorhabditis elegans. Salzberg Y, et al. PLoS Genet, 2014 Sep. PMID 25232734, Free PMC Article
    4. Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions. Dong X, et al. Elife, 2016 Mar 14. PMID 26974341, Free PMC Article
    5. A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans. Zou W, et al. Elife, 2016 Oct 5. PMID 27705746, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MNR-1 or menorin (gene W01F3.1) acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites.
      Title: Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans.
    2. The ligand complex SAX-7/L1CAM and MNR-1 (gene W01F3.1) function at defined locations in the surrounding hypodermal tissue, whereas DMA-1 acts as the cognate receptor on the sensory neuron PVD. Mutations in this complex lead to dramatic defects in the formation, stabilization, and organization of the dendritic arbor.
      Title: An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite self-avoidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dendrite self-avoidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendrite morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Menorin
    NP_507990.1
    • Confirmed by transcript evidence
    NP_507991.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20654650..20659744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075590.6 → NP_507991.1  Menorin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507991.1

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam10223
      Location:41 → 236
      DUF2181; Uncharacterized conserved protein (DUF2181)

    2. NM_075589.8 → NP_507990.1  Menorin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507990.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45879, O45880, Q9BI60
      Conserved Domains (1) summary
      pfam10223
      Location:41 → 290
      DUF2181; Uncharacterized conserved protein (DUF2181)
    Nucleotide Protein
    Heading Accession and Version

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