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    citk-2 non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

    Gene ID: 173864, updated on 9-Dec-2024

    Summary

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    Official Symbol
    citk-2
    Official Full Name
    non-specific serine/threonine protein kinase
    Primary source
    WormBase:WBGene00019087
    Locus tag
    CELE_F59A6.5
    See related
    AllianceGenome:WB:WBGene00019087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; metal ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in actomyosin structure organization. Predicted to be active in cytoplasm and cytoskeleton. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17 and primary microcephaly. Orthologous to human CIT (citron rho-interacting serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See citk-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (4999520..5003806)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Charged multivesicular body protein 3 Neighboring gene Ribonuclease H1;Ribonuclease H1 N-terminal domain-containing protein Neighboring gene Conserved secreted protein Neighboring gene TIL domain-containing protein Neighboring gene Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging. Park WS, et al. Mol Cell, 2008 May 9. PMID 18471983, Free PMC Article
    2. Cytokinesis is not controlled by calmodulin or myosin light chain kinase in the Caenorhabditis elegans early embryo. Batchelder EL, et al. FEBS Lett, 2007 Sep 4. PMID 17716666, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    non-specific serine/threonine protein kinase
    NP_494921.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4999520..5003806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062520.6 → NP_494921.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21025
      Conserved Domains (6) summary
      smart00036
      Location:965 → 1248
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00233
      Location:835 → 940
      PH; Pleckstrin homology domain
      COG1340
      Location:341 → 645
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:758 → 808
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00169
      Location:835 → 940
      PH; PH domain
      pfam14662
      Location:235 → 436
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
    Nucleotide Protein
    Heading Accession and Version

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