U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mon-2 Monensin-resistant homolog 2 [ Caenorhabditis elegans ]

    Gene ID: 178153, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mon-2
    Official Full Name
    Monensin-resistant homolog 2
    Primary source
    WormBase:WBGene00008685
    Locus tag
    CELE_F11A10.4
    See related
    AllianceGenome:WB:WBGene00008685
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in protein transport. Predicted to be located in Golgi apparatus. Is expressed in several structures, including intestine. Orthologous to human MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mon-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    14
    Sequence:
    Chromosome: IV; NC_003282.8 (12096779..12105786)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cleavage and polyadenylation specificity factor subunit 4 Neighboring gene Protein ST7 homolog Neighboring gene Asparagine synthetase domain-containing protein Neighboring gene Collagen triple helix repeat protein;Nematode cuticle collagen N-terminal domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans. Jung Y, et al. Sci Adv, 2021 Dec 3. PMID 34860542, Free PMC Article
    2. MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications. Artan M, et al. Autophagy, 2022 May. PMID 35188063, Free PMC Article
    3. Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans. Zhu M, et al. PLoS One, 2015. PMID 26115433, Free PMC Article
    4. SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion. McGough IJ, et al. Nat Commun, 2018 Sep 13. PMID 30213940, Free PMC Article
    5. Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions. Kanamori T, et al. EMBO J, 2008 Jun 18. PMID 18497747, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Monensin-resistant homolog 2
    NP_001255622.1
    • Confirmed by transcript evidence
    NP_001255623.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12096779..12105786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268694.2 → NP_001255623.1  Monensin-resistant homolog 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255623.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19338
      Conserved Domains (4) summary
      pfam09324
      Location:833 → 901
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:214 → 395
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:909 → 1615
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:7 → 184
      DCB; Dimerization and cyclophilin-binding domain of Mon2

    2. NM_001268693.3 → NP_001255622.1  Monensin-resistant homolog 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBK9, Q19338, Q21561
      Conserved Domains (4) summary
      pfam09324
      Location:833 → 901
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:214 → 395
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:909 → 1613
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:7 → 184
      DCB; Dimerization and cyclophilin-binding domain of Mon2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19338.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools