U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    rhy-1 Regulator of hypoxia-inducible factor 1 [ Caenorhabditis elegans ]

    Gene ID: 174455, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rhy-1
    Official Full Name
    Regulator of hypoxia-inducible factor 1
    Primary source
    WormBase:WBGene00012324
    Locus tag
    CELE_W07A12.7
    See related
    AllianceGenome:WB:WBGene00012324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Involved in negative regulation of cellular response to hypoxia and response to hypoxia. Located in perinuclear region of cytoplasm. Is expressed in several structures, including body wall musculature; intestine; neurons; socket cell; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rhy-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (9161379..9163448)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Col_cuticle_N domain-containing protein Neighboring gene Acyltransferase 3 domain-containing protein Neighboring gene DapB_N domain-containing protein Neighboring gene G-patch domain-containing protein Neighboring gene Calcineurin-like phosphoesterase domain-containing protein Neighboring gene Transcription factor dpl-1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A Novel Mechanism To Prevent H(2)S Toxicity in Caenorhabditis elegans. Horsman JW, et al. Genetics, 2019 Oct. PMID 31371406, Free PMC Article
    2. Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection. Burton NO, et al. Nat Commun, 2020 Apr 8. PMID 32269224, Free PMC Article
    3. Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans. Warnhoff K, et al. Elife, 2024 Feb 13. PMID 38349720, Free PMC Article
    4. Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans. Bellier A, et al. PLoS Pathog, 2009 Dec. PMID 20011506, Free PMC Article
    5. Co-opted genes of algal origin protect C. elegans against cyanogenic toxins. Wang B, et al. Curr Biol, 2022 Nov 21. PMID 36223775, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.
      Title: Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.
    2. The rhy-1 gene encodes a predicated O-acyltransferase enzyme that has previously been shown to negatively regulate HIF-1 activity. Our data indicate that RHY-1 has novel, hif-1 independent, function that promotes survival in H2S.
      Title: A Novel Mechanism To Prevent H(2)S Toxicity in Caenorhabditis elegans.
    3. The Caenorhabditis elegans rhy-1 gene inhibits hif-1 activity in a negative feedback loop that does not include vhl-1.
      Title: The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hypoxia IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Regulator of hypoxia-inducible factor 1
    NP_495954.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9161379..9163448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063553.5 → NP_495954.1  Regulator of hypoxia-inducible factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495954.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XVW1
      Conserved Domains (2) summary
      COG1835
      Location:89 → 489
      OafA; Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis]
      pfam01757
      Location:95 → 479
      Acyl_transf_3; Acyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XVW1.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools