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    sco-1 Thioredoxin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173763, updated on 9-Dec-2024

    Summary

    Official Symbol
    sco-1
    Official Full Name
    Thioredoxin domain-containing protein
    Primary source
    WormBase:WBGene00015297
    Locus tag
    CELE_C01F1.2
    See related
    AllianceGenome:WB:WBGene00015297
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable copper chaperone activity and copper ion binding activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrial inner membrane. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease; hypertrophic cardiomyopathy; mitochondrial complex IV deficiency nuclear type 2; mitochondrial complex IV deficiency nuclear type 4; and myopia. Orthologous to several human genes including SCO1 (synthesis of cytochrome C oxidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See sco-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (4299653..4300845)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NAD(P)-bd_dom domain-containing protein;NAD(P)-binding domain-containing protein Neighboring gene Transcription initiation factor IIF subunit alpha Neighboring gene protein-disulfide reductase Neighboring gene UNC93-like protein MFSD11

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables copper chaperone activity  
    enables copper ion binding  
    enables metal ion binding  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane  
    located_in mitochondrion  

    General protein information

    Preferred Names
    Thioredoxin domain-containing protein
    NP_494755.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4299653..4300845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062354.7NP_494755.1  Thioredoxin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17557
      Conserved Domains (1) summary
      cd02968
      Location:137281
      SCO; SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c ...
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