vps-25 Vacuolar protein-sorting-associated protein 25 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vps-25
Official Full Name: Vacuolar protein-sorting-associated protein 25
Primary source: WormBase:WBGene00012193
Locus tag: CELE_W02A11.2
See related: AllianceGenome:WB:WBGene00012193
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein homodimerization activity and structural molecule activity. Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT II complex. Is expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Orthologous to human VPS25 (vacuolar protein sorting 25 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vps-25 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (12733287..12741275, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the data in this study present here the first direct evidence that ESCRT-II components VPS-36, VPS-22 and VPS-25 share a specific sarcoplasmic reticulum sub-cellular localization in C. elegans muscle cells and are involved in sarcoplasmic reticulum shaping.
Title: The ESCRT-II proteins are involved in shaping the sarcoplasmic reticulum in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-209 (e-PCR)
- UniSTS:241701

W02A11.2 (e-PCR)
- UniSTS:322350

W02A11.3 (e-PCR)
- UniSTS:305916

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of ESCRT II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT II complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Vacuolar protein-sorting-associated protein 25

NP_001379220.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

12733287..12741275 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392958.1 → NP_001379220.1 Vacuolar protein-sorting-associated protein 25 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q9U354

Conserved Domains (1) summary

pfam05871
Location:16 → 145

ESCRT-II; ESCRT-II complex subunit