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    dgk-2 DAGKc domain-containing protein;Diacylglycerol kinase [ Caenorhabditis elegans ]

    Gene ID: 180720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dgk-2
    Official Full Name
    DAGKc domain-containing protein;Diacylglycerol kinase
    Primary source
    WormBase:WBGene00000959
    Locus tag
    CELE_F46H6.2
    See related
    AllianceGenome:WB:WBGene00000959
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in glycerolipid metabolic process and intracellular signal transduction. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 7. Orthologous to human DGKE (diacylglycerol kinase epsilon). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dgk-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (4494919..4504388, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion. Edwards MR, et al. J Neurosci, 2012 May 16. PMID 22593072, Free PMC Article
    2. Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans. Matsuki M, et al. Proc Natl Acad Sci U S A, 2006 Jan 24. PMID 16418272, Free PMC Article
    3. Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma. Espelt MV, et al. J Gen Physiol, 2005 Oct. PMID 16186564, Free PMC Article
    4. Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. Wilson CH, et al. EMBO J, 2012 May 30. PMID 22510880, Free PMC Article
    5. Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans. Tanizawa Y, et al. Genes Dev, 2006 Dec 1. PMID 17158747, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DAGKc domain-containing protein;Diacylglycerol kinase
    NP_001024679.1
    • Confirmed by transcript evidence
    NP_001024680.1
    • Confirmed by transcript evidence
    NP_001379634.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4494919..4504388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029508.6 → NP_001024679.1  Diacylglycerol kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024679.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYI9
      Conserved Domains (3) summary
      cd00029
      Location:110 → 159
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00781
      Location:203 → 325
      DAGK_cat; Diacylglycerol kinase catalytic domain
      cl02440
      Location:350 → 503
      DAGK_acc; Diacylglycerol kinase accessory domain

    2. NM_001392762.1 → NP_001379634.1  Diacylglycerol kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z299
      Conserved Domains (2) summary
      pfam00781
      Location:18 → 140
      DAGK_cat; Diacylglycerol kinase catalytic domain
      cl02440
      Location:165 → 318
      DAGK_acc; Diacylglycerol kinase accessory domain

    3. NM_001029509.6 → NP_001024680.1  DAGKc domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024680.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z2A0
      Conserved Domains (1) summary
      pfam00781
      Location:18 → 126
      DAGK_cat; Diacylglycerol kinase catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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