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    spcs-1 Signal peptidase complex subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 172967, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spcs-1
    Official Full Name
    Signal peptidase complex subunit 1
    Primary source
    WormBase:WBGene00016395
    Locus tag
    CELE_C34B2.10
    See related
    AllianceGenome:WB:WBGene00016395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in IRE1-mediated unfolded protein response. Located in endoplasmic reticulum. Orthologous to human SPCS1 (signal peptidase complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spcs-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (10682472..10683048, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene TPR_REGION domain-containing protein Neighboring gene Lon protease homolog, mitochondrial Neighboring gene Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Rolls MM, et al. Mol Biol Cell, 2002 May. PMID 12006669, Free PMC Article
    2. Alternative redox forms of ASNA-1 separate insulin signaling from tail-anchored protein targeting and cisplatin resistance in C. elegans. Raj D, et al. Sci Rep, 2021 Apr 21. PMID 33883621, Free PMC Article
    3. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. Wang C, et al. Nat Commun, 2022 Nov 10. PMID 36357390, Free PMC Article
    4. Multiple phenotypes resulting from a mutagenesis screen for pharynx muscle mutations in Caenorhabditis elegans. Ferrier A, et al. PLoS One, 2011. PMID 22073173, Free PMC Article
    5. Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans. Poteryaev D, et al. Mol Biol Cell, 2005 May. PMID 15716356, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Signal peptidase complex subunit 1
    NP_492797.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10682472..10683048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060396.6 → NP_492797.1  Signal peptidase complex subunit 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492797.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44953
      Conserved Domains (1) summary
      pfam06645
      Location:19 → 90
      SPC12; Microsomal signal peptidase 12 kDa subunit (SPC12)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44953.1

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