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    hlh-12 Helix-loop-helix protein hlh-12 [ Caenorhabditis elegans ]

    Gene ID: 182980, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hlh-12
    Official Full Name
    Helix-loop-helix protein hlh-12
    Primary source
    WormBase:WBGene00001956
    Locus tag
    CELE_C28C12.8
    See related
    AllianceGenome:WB:WBGene00001956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in gonad morphogenesis; positive regulation of distal tip cell migration; and positive regulation of gene expression. Located in nucleus. Is expressed in distal tip cell and linker cell. Orthologous to human FERD3L (Fer3 like bHLH transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hlh-12 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (8478595..8479446, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Transmembrane protein Neighboring gene Saposin B-type domain-containing protein Neighboring gene Saposin B-type domain-containing protein Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A "FLP-Out" system for controlled gene expression in Caenorhabditis elegans. Voutev R, et al. Genetics, 2008 Sep. PMID 18723890, Free PMC Article
    2. hlh-12, a gene that is necessary and sufficient to promote migration of gonadal regulatory cells in Caenorhabditis elegans, evolved within the Caenorhabditis clade. Littleford HE, et al. Genetics, 2021 Nov 5. PMID 34740245, Free PMC Article
    3. Transcription factor hlh-2/E/Daughterless drives expression of α integrin ina-1 during DTC migration in C. elegans. Meighan CM, et al. Gene, 2015 Sep 1. PMID 25982859
    4. bHLH transcription factors regulate organ morphogenesis via activation of an ADAMTS protease in C. elegans. Tamai KK, et al. Dev Biol, 2007 Aug 15. PMID 17588558
    5. Floxed exon (Flexon): A flexibly positioned stop cassette for recombinase-mediated conditional gene expression. Shaffer JM, et al. Proc Natl Acad Sci U S A, 2022 Jan 18. PMID 35027456, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hlh-12, a gene that is necessary and sufficient to promote migration of gonadal regulatory cells in Caenorhabditis elegans, evolved within the Caenorhabditis clade.
      Title: hlh-12, a gene that is necessary and sufficient to promote migration of gonadal regulatory cells in Caenorhabditis elegans, evolved within the Caenorhabditis clade.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of distal tip cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Helix-loop-helix protein hlh-12
    NP_501445.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8478595..8479446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069044.5 → NP_501445.1  Helix-loop-helix protein hlh-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501445.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18277
      Conserved Domains (1) summary
      pfam00010
      Location:14 → 66
      HLH; Helix-loop-helix DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18277.1

    Gene LinkOut

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