bag-1 BAG family molecular chaperone regulator 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: bag-1
Official Full Name: BAG family molecular chaperone regulator 1
Primary source: WormBase:WBGene00000236
Locus tag: CELE_F57B10.11
See related: AllianceGenome:WB:WBGene00000236
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ATPase activator activity. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein stabilization. Predicted to be active in cytosol; membrane; and nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BAG1 (BAG cochaperone 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See bag-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (6563629..6564451, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F57B10.11 (e-PCR)
- UniSTS:320993

F57B10.12 (e-PCR)
- UniSTS:305649

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: BAG family molecular chaperone regulator 1

NP_491893.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6563629..6564451 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059492.8 → NP_491893.1 BAG family molecular chaperone regulator 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491893.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44739

Conserved Domains (2) summary

cd01769
Location:23 → 79

UBL; Ubiquitin-like domain of UBL

smart00264
Location:111 → 193

BAG; BAG domains, present in regulator of Hsp70 proteins