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    prx-10 Peroxisome biogenesis factor 10;Tryptophan--tRNA ligase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 175719, updated on 9-Dec-2024

    Summary

    Official Symbol
    prx-10
    Official Full Name
    Peroxisome biogenesis factor 10;Tryptophan--tRNA ligase, mitochondrial
    Primary source
    WormBase:WBGene00006946
    Locus tag
    CELE_C34E10.4
    See related
    AllianceGenome:WB:WBGene00006946
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tryptophan-tRNA ligase activity. Predicted to be involved in mitochondrial tryptophanyl-tRNA aminoacylation. Predicted to be located in peroxisomal membrane. Predicted to be active in mitochondrial matrix. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See prx-10 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (5236410..5240055)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein arginine N-methyltransferase 5 Neighboring gene Small ribosomal subunit protein mS26 Neighboring gene Neurogenic differentiation factor 1 Neighboring gene Protein sumv-1

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables aminoacyl-tRNA ligase activity  
    enables metal ion binding  
    enables nucleotide binding  
    enables transferase activity  
    enables tryptophan-tRNA ligase activity  
    enables tryptophan-tRNA ligase activity  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in mitochondrial tryptophanyl-tRNA aminoacylation  
    involved_in peroxisome organization  
    involved_in protein import into peroxisome matrix  
    involved_in protein transport  
    involved_in protein ubiquitination  
    involved_in tRNA aminoacylation for protein translation  
    involved_in translation  
    involved_in tryptophanyl-tRNA aminoacylation  
    Component Evidence Code Pubs
    located_in membrane  
    is_active_in mitochondrial matrix  
    located_in mitochondrial matrix  
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in peroxisomal membrane  
    located_in peroxisome  

    General protein information

    Preferred Names
    Peroxisome biogenesis factor 10;Tryptophan--tRNA ligase, mitochondrial
    NP_001021200.2
    • Confirmed by transcript evidence
    NP_001379766.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5236410..5240055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026029.5 → NP_001021200.2  Peroxisome biogenesis factor 10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021200.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0HKD7, P46579, Q5TYM1, Q7Z259
      Conserved Domains (2) summary
      COG5574
      Location:162 → 308
      PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
      pfam04757
      Location:18 → 222
      Pex2_Pex12; Pex2 / Pex12 amino terminal region
    2. NM_001392091.1 → NP_001379766.1  Tryptophan--tRNA ligase, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0HKD6
      Conserved Domains (1) summary
      PRK00927
      Location:34 → 360
      PRK00927; tryptophanyl-tRNA synthetase; Reviewed
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