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    grd-11 GRounDhog (hedgehog-like family) [ Caenorhabditis elegans ]

    Gene ID: 186880, updated on 9-Dec-2024

    Summary

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    Official Symbol
    grd-11
    Official Full Name
    GRounDhog (hedgehog-like family)
    Primary source
    WormBase:WBGene00001700
    Locus tag
    CELE_K02E2.2
    See related
    AllianceGenome:WB:WBGene00001700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in protein autoprocessing. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal (multiple); Hirschsprung's disease; bone development disease (multiple); holoprosencephaly (multiple); and hypoplastic or aplastic tibia with polydactyly. Orthologous to human IHH (Indian hedgehog signaling molecule); DHH (desert hedgehog signaling molecule); and SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See grd-11 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    15
    Sequence:
    Chromosome: V; NC_003283.11 (20356772..20365773)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Asn Neighboring gene Sodium-and chloride-dependent glycine transporter 2 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene DUF281 domain-containing protein Neighboring gene Serpentine Receptor, class H Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans. Abete-Luzi P, et al. Genetics, 2020 Mar. PMID 31974205, Free PMC Article
    2. Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis. Aspöck G, et al. Genome Res, 1999 Oct. PMID 10523520
    3. Comprehensive analysis of gene expression patterns of hedgehog-related genes. Hao L, et al. BMC Genomics, 2006 Oct 31. PMID 17076889, Free PMC Article
    4. The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans. Zugasti O, et al. Genome Res, 2005 Oct. PMID 16204193, Free PMC Article
    5. Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif. Bürglin TR. BMC Genomics, 2008 Mar 11. PMID 18334026, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GRounDhog (hedgehog-like family)
    NP_507923.2
    • Product from WormBase gene class grd;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20356772..20365773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075522.4 → NP_507923.2  GRounDhog (hedgehog-like family) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507923.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUV2
      Conserved Domains (3) summary
      cd00081
      Location:758 → 920
      Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
      pfam01079
      Location:758 → 974
      Hint; Hint module
      pfam04155
      Location:262 → 343
      Ground-like; Ground-like domain
    Nucleotide Protein
    Heading Accession and Version

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