ceh-16 Homeobox protein engrailed-like ceh-16 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ceh-16
Official Full Name: Homeobox protein engrailed-like ceh-16
Primary source: WormBase:WBGene00000439
Locus tag: CELE_C13G5.1
See related: AllianceGenome:WB:WBGene00000439
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables sequence-specific DNA binding activity. Involved in several processes, including embryonic body morphogenesis; epidermal cell fate specification; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including ABaraa; head; hyp5; retrovesicular ganglion neurons; and seam cell. Human ortholog(s) of this gene implicated in Parkinson's disease and autistic disorder. Orthologous to human EN1 (engrailed homeobox 1) and EN2 (engrailed homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ceh-16 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (8622735..8626298)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ceh-16 interacts with the Wnt signaling pathway to control the choice between self-renewal expansion and maintenance division
Title: The C. elegans engrailed homolog ceh-16 regulates the self-renewal expansion division of stem cell-like seam cells.
patterns the embryonic epidermis of Caenorhabditis elegans
Title: ceh-16/engrailed patterns the embryonic epidermis of Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C13G5.1 (e-PCR)
- UniSTS:321933

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in formation of anatomical boundary	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Homeobox protein engrailed-like ceh-16

NP_001379631.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8622735..8626298

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392158.1 → NP_001379631.1 Homeobox protein engrailed-like ceh-16 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P34326, P90748, Q6DTF7

Conserved Domains (1) summary

pfam00046
Location:90 → 144

Homeobox; Homeobox domain