cysl-1 Cysteine synthase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cysl-1
Official Full Name: Cysteine synthase 1
Primary source: WormBase:WBGene00007653
Locus tag: CELE_C17G1.7
See related: AllianceGenome:WB:WBGene00007653
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cysteine synthase activity and enzyme binding activity. Involved in cysteine biosynthetic process from serine and response to hypoxia. Located in striated muscle dense body. Is expressed in several structures, including body wall musculature; head ganglion; intestine; neurons; and non-striated muscle. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cysl-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (9952579..9954533, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These observations establish a CYSL-1, CYSL-2, and RHY-1 dependent mechanism by which animals heritably adapt to infection.
Title: Cysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection.
CYSL-1 interacts with EGL-9 and activates HIF-1 that upregulates expression of genes detoxifying sulfide and cyanide, the CYSL-2 acts as a cyanoalanine synthase in the cyanide detoxification pathway and simultaneously produces hydrogen sulfide
Title: Biochemical properties of nematode O-acetylserine(thiol)lyase paralogs imply their distinct roles in hydrogen sulfide homeostasis.
Data indicate that genes sqrd-1, ethe-1, cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide and hydrogen cyanide.
Title: The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C17G1.7 (e-PCR)
- UniSTS:307262

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine synthase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cysteine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process from serine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cysteine biosynthetic process from serine	IDA Inferred from Direct Assay more info	PubMed
involved_in cysteine biosynthetic process from serine	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in striated muscle dense body	HDA more info	PubMed

General protein information

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Preferred Names: Cysteine synthase 1

NP_001369978.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9952579..9954533 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383632.2 → NP_001369978.1 Cysteine synthase 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93244

Conserved Domains (1) summary

cd01561
Location:16 → 306

CBS_like; This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of ...