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    pap-2 Poly(A) polymerase [ Caenorhabditis elegans ]

    Gene ID: 174513, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pap-2
    Official Full Name
    Poly(A) polymerase
    Primary source
    WormBase:WBGene00011791
    Locus tag
    CELE_T15H9.6
    See related
    AllianceGenome:WB:WBGene00011791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in RNA 3'-end processing and mRNA processing. Predicted to be active in nucleus. Orthologous to several human genes including PAPOLB (poly(A) polymerase beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pap-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003280.10 (9607732..9609396, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Adenylate kinase isoenzyme 6 homolog Neighboring gene Mitochondrial Ribosomal Protein, Large Neighboring gene Nuclear hormone receptor family member nhr-19 Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Lehrbach NJ, et al. Nat Struct Mol Biol, 2009 Oct. PMID 19713957, Free PMC Article
    2. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Poly(A) polymerase
    NP_496067.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9607732..9609396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063666.5 → NP_496067.1  Poly(A) polymerase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496067.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09995
      Conserved Domains (1) summary
      pfam04928
      Location:15 → 361
      PAP_central; Poly(A) polymerase central domain
    Nucleotide Protein
    Heading Accession and Version

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