vdac-1 putative voltage-dependent anion-selective channel [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vdac-1
Official Full Name: putative voltage-dependent anion-selective channel
Primary source: WormBase:WBGene00019900
Locus tag: CELE_R05G6.7
See related: AllianceGenome:WB:WBGene00019900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable voltage-gated monoatomic anion channel activity. Involved in mitochondrion organization. Acts upstream of or within with a positive effect on olfactory behavior. Located in mitochondrion. Is expressed in several structures, including enteric muscle; head mesodermal cell; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including VDAC1 (voltage dependent anion channel 1) and VDAC2 (voltage dependent anion channel 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vdac-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (7506427..7507891, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MIRO-1 interacts with VDAC-1 to regulate mitochondrial membrane potential in Caenorhabditis elegans.
Title: MIRO-1 interacts with VDAC-1 to regulate mitochondrial membrane potential in Caenorhabditis elegans.
Functions of VDAC-1 in Amphid Wing "C" neurons are essential for normal olfactory reception in C. elegans. VDAC-1 function is regulated by phosphorylation and identified Thr175 as the potential phosphorylation site of MAP kinase.
Title: Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R05G6.5 (e-PCR)
- UniSTS:316945

R05G6.7 (e-PCR)
- UniSTS:312059

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables porin activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of pore complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative voltage-dependent anion-selective channel

NP_501211.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

7506427..7507891 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068810.9 → NP_501211.1 putative voltage-dependent anion-selective channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501211.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21752

Conserved Domains (1) summary

cd07306
Location:3 → 280

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane