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    aat-2 Amino Acid Transporter [ Caenorhabditis elegans ]

    Gene ID: 184126, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aat-2
    Official Full Name
    Amino Acid Transporter
    Primary source
    WormBase:WBGene00000003
    Locus tag
    CELE_F07C3.7
    See related
    AllianceGenome:WB:WBGene00000003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to human SLC7A5 (solute carrier family 7 member 5) and SLC7A8 (solute carrier family 7 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aat-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (9244402..9246360, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene X-linked retinitis pigmentosa GTPase regulator homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Seven TM Receptor Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of AAT transporters in methylmercury toxicity in Caenorhabditis elegans. Caito SW, et al. Biochem Biophys Res Commun, 2013 Jun 14. PMID 23669041, Free PMC Article
    2. Guarana (Paullinia cupana Mart.) attenuates methylmercury-induced toxicity in Caenorhabditis elegans. Arantes LP, et al. Toxicol Res (Camb), 2016 Nov 1. PMID 28316775, Free PMC Article
    3. Functional characterization of Caenorhabditis elegans heteromeric amino acid transporters. Veljkovic E, et al. J Biol Chem, 2004 Feb 27. PMID 14668347
    4. Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Sarin S, et al. Nat Methods, 2008 Oct. PMID 18677319, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Amino Acid Transporter
    NP_505394.2
    • Product from WormBase gene class aat;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9244402..9246360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072993.6 → NP_505394.2  Amino Acid Transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505394.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19151
      Conserved Domains (1) summary
      TIGR00911
      Location:1 → 477
      2A0308; L-type amino acid transporter
    Nucleotide Protein
    Heading Accession and Version

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