mes-2 Histone-lysine N-methyltransferase mes-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mes-2
Official Full Name: Histone-lysine N-methyltransferase mes-2
Primary source: WormBase:WBGene00003220
Locus tag: CELE_R06A4.7
See related: AllianceGenome:WB:WBGene00003220
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables histone H3K27 methyltransferase activity. Involved in epigenetic regulation of gene expression; germ-line stem cell division; and tissue development. Part of PcG protein complex and nucleosome. Is expressed in Z2; Z3; germ line; hypodermis; and intestine. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) and EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mes-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (14383973..14388454)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner.
Title: H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner.
mes-2 orchestrates large-scale changes in chromatin organization and gene expression to promote the timely loss of developmental plasticity.
Title: The polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos.
The SET domain of MES-2 functions as a histone h3 methyltransferase in X chromosome inactivation.
Title: The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegans.
mes-2 represses Hox expression, causing anteroposterior transformations and disrupts Hox-dependent neuroblast migration.
Title: Polycomb group regulation of Hox gene expression in C. elegans.
mes-2 mutants suppress mab-3.
Title: Finally, worm polycomb-like genes meet Hox regulation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R06A4.6 (e-PCR)
- UniSTS:307839

R06A4.7 (e-PCR)
- UniSTS:313277

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K27 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K27 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K27 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PcG protein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of nucleosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Histone-lysine N-methyltransferase mes-2

NP_496992.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14383973..14388454

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064591.7 → NP_496992.3 Histone-lysine N-methyltransferase mes-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496992.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O17514, O62335

Conserved Domains (2) summary

smart00317
Location:621 → 742

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

pfam13845
Location:210 → 265

Septum_form; Septum formation