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    F22G12.4 ANK_REP_REGION domain-containing protein;FYVE-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173180, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F22G12.4
    Official Full Name
    ANK_REP_REGION domain-containing protein;FYVE-type domain-containing protein
    Primary source
    WormBase:WBGene00009064
    Locus tag
    CELE_F22G12.4
    See related
    AllianceGenome:WB:WBGene00009064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 1-phosphatidylinositol binding activity. Orthologous to human ANKFY1 (ankyrin repeat and FYVE domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F22G12.4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    16
    Sequence:
    Chromosome: I; NC_003279.8 (13155224..13161508, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene F-box domain-containing protein Neighboring gene tRNA-Val Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene DOCKER domain-containing protein;PH domain-containing protein Neighboring gene Defensin-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Hayakawa A, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16873553, Free PMC Article
    2. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ANK_REP_REGION domain-containing protein;FYVE-type domain-containing protein
    NP_001252085.1
    • Confirmed by transcript evidence
    NP_001252086.1
    • Confirmed by transcript evidence
    NP_001252087.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13155224..13161508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001265156.2 → NP_001252085.1  ANK_REP_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252085.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45398
      Conserved Domains (7) summary
      smart00225
      Location:64 → 158
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd00204
      Location:593 → 741
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00651
      Location:58 → 158
      BTB; BTB/POZ domain
      pfam12796
      Location:440 → 529
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:649 → 685
      ANK; ANK repeat [structural motif]
      cl06652
      Location:162 → 190
      BACK_like; BTB-And-C-terminal-Kelch (BACK) domain and similar domains
      cl22851
      Location:1039 → 1099
      PHD_SF; PHD finger superfamily

    2. NM_001265157.3 → NP_001252086.1  FYVE-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G1K106
      Conserved Domains (4) summary
      cd00204
      Location:389 → 537
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:236 → 325
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:445 → 481
      ANK; ANK repeat [structural motif]
      cl22851
      Location:835 → 895
      PHD_SF; PHD finger superfamily

    3. NM_001265158.3 → NP_001252087.1  FYVE-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252087.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G1K105
      Conserved Domains (4) summary
      cd00204
      Location:296 → 444
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:143 → 232
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:352 → 388
      ANK; ANK repeat [structural motif]
      cl22851
      Location:742 → 802
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version

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