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    sqst-1 ZZ-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178139, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sqst-1
    Official Full Name
    ZZ-type domain-containing protein
    Primary source
    WormBase:WBGene00011737
    Locus tag
    CELE_T12G3.1
    See related
    AllianceGenome:WB:WBGene00011737
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and protein kinase C binding activity. Predicted to be involved in aggrephagy; endosome organization; and mitophagy. Located in cytoplasm. Is expressed in several structures, including hypodermal cell; intestine; nervous system; pharynx; and reproductive system. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis 3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sqst-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (12034282..12036891)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RWD domain-containing protein Neighboring gene Large ribosomal subunit protein mL51 Neighboring gene CULLIN_2 domain-containing protein;Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy. Kumsta C, et al. Nat Commun, 2019 Dec 11. PMID 31827090, Free PMC Article
    2. The tissue- and developmental stage-specific involvement of autophagy genes in aggrephagy. Zheng H, et al. Autophagy, 2020 Apr. PMID 31204564, Free PMC Article
    3. Monitoring autophagic flux in Caenorhabditis elegans using a p62/SQST-1 reporter. Ploumi C, et al. Methods Cell Biol, 2021. PMID 34311872
    4. Disrupted autophagy and neuronal dysfunction in C. elegans knockin models of FUS amyotrophic lateral sclerosis. Baskoylu SN, et al. Cell Rep, 2022 Jan 25. PMID 35081350
    5. Guidelines for monitoring autophagy in Caenorhabditis elegans. Zhang H, et al. Autophagy, 2015. PMID 25569839, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.
      Title: The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aggrephagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in aggresome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in amphisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ZZ-type domain-containing protein
    NP_001255608.1
    • Confirmed by transcript evidence
    NP_001255609.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12034282..12036891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268679.3 → NP_001255608.1  ZZ-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22436
      Conserved Domains (3) summary
      smart00165
      Location:657 → 692
      UBA; Ubiquitin associated domain
      cd02340
      Location:182 → 224
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      pfam16788
      Location:457 → 580
      ATF7IP_BD; ATF-interacting protein binding domain

    2. NM_001268680.3 → NP_001255609.1  ZZ-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F1LIM5
      Conserved Domains (3) summary
      smart00165
      Location:585 → 620
      UBA; Ubiquitin associated domain
      cd02340
      Location:110 → 152
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      pfam16788
      Location:385 → 508
      ATF7IP_BD; ATF-interacting protein binding domain
    Nucleotide Protein
    Heading Accession and Version

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