nos-1 Nanos-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nos-1
Official Full Name: Nanos-type domain-containing protein
Primary source: WormBase:WBGene00003783
Locus tag: CELE_R03D7.7
See related: AllianceGenome:WB:WBGene00003783
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA binding activity. Involved in medium-term memory and short-term memory. Predicted to be located in cytoplasm. Predicted to be active in perinuclear region of cytoplasm. Is expressed in Z2 and Z3. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Orthologous to human NANOS1 (nanos C2HC-type zinc finger 1); NANOS2 (nanos C2HC-type zinc finger 2); and NANOS3 (nanos C2HC-type zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nos-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (10951592..10953165, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that nos-1 and nos-2 activity is required in primordial germ cells to silence maternal transcripts inherited from the oocyte. We identify maternal lin-15B as a critical target of Nanos regulation that must be turned-over to establish MES methyltransferase dominance in primordial germ cells.
Title: Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B.
xnd-1 defines a new branch for PGC development that functions redundantly with nos-2 and nos-1 to promote germline fates by maintaining transcriptional quiescence and regulating germ cell proliferation
Title: A germ cell determinant reveals parallel pathways for germ line development in Caenorhabditis elegans.
Data indicate that meg-1 and meg-2 differentially interact with the nanos family nos-1, nos-2 and nos-3 for germ cell proliferaiton.
Title: C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R03D7.7 (e-PCR)
- UniSTS:307829

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Nanos-type domain-containing protein

NP_496358.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10951592..10953165 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063957.3 → NP_496358.1 Nanos-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496358.1

Status: REVIEWED

UniProtKB/TrEMBL

Q09597

Conserved Domains (1) summary

pfam05741
Location:240 → 304

zf-nanos; Nanos RNA binding domain