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    ipgm-1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [ Caenorhabditis elegans ]

    Gene ID: 172376, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ipgm-1
    Official Full Name
    2,3-bisphosphoglycerate-independent phosphoglycerate mutase
    Primary source
    WormBase:WBGene00019001
    Locus tag
    CELE_F57B10.3
    See related
    AllianceGenome:WB:WBGene00019001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity. Involved in carbohydrate metabolic process. Predicted to be located in cytoplasm. Is expressed in body wall musculature; intestine; and nerve ring. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ipgm-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (6569557..6572600)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Meiotic spindle formation protein 2 Neighboring gene Protein MRVI1;Thyroid receptor-interacting protein 11 Neighboring gene CREB-H transcription factor homolog let-607 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases. Yu H, et al. Nat Commun, 2017 Apr 3. PMID 28368002, Free PMC Article
    2. Molecular and biochemical characterization of nematode cofactor independent phosphoglycerate mutases. Raverdy S, et al. Mol Biochem Parasitol, 2007 Dec. PMID 17897734
    3. Cofactor-independent phosphoglycerate mutase has an essential role in Caenorhabditis elegans and is conserved in parasitic nematodes. Zhang Y, et al. J Biol Chem, 2004 Aug 27. PMID 15234973
    4. Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease. Taylor RC, et al. J Biol Chem, 2007 May 18. PMID 17371877
    5. Spatial single-cell sequencing of meiosis I arrested oocytes indicates acquisition of maternal transcripts from the soma. Trimmer KA, et al. Cell Rep, 2023 Jun 27. PMID 37227820, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglycerate mutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2,3-bisphosphoglycerate-independent phosphoglycerate mutase
    NP_491896.1
    • Confirmed by transcript evidence
    NP_871851.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6569557..6572600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059495.6 → NP_491896.1  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491896.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFZ1, Q8IA68
      Conserved Domains (2) summary
      PRK05434
      Location:30 → 536
      PRK05434; phosphoglyceromutase; Provisional
      cd16010
      Location:29 → 536
      iPGM; 2 3 bisphosphoglycerate independent phosphoglycerate mutase iPGM

    2. NM_182051.6 → NP_871851.1  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871851.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFZ1
      Conserved Domains (2) summary
      PRK05434
      Location:12 → 518
      PRK05434; phosphoglyceromutase; Provisional
      cd16010
      Location:11 → 518
      iPGM; 2 3 bisphosphoglycerate independent phosphoglycerate mutase iPGM
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFZ1.1

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