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    tpst-1 Protein-tyrosine sulfotransferase A [ Caenorhabditis elegans ]

    Gene ID: 176684, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tpst-1
    Official Full Name
    Protein-tyrosine sulfotransferase A
    Primary source
    WormBase:WBGene00013737
    Locus tag
    CELE_Y111B2A.15
    See related
    AllianceGenome:WB:WBGene00013737
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein-tyrosine sulfotransferase activity. Involved in several processes, including collagen metabolic process; cuticle development involved in collagen and cuticulin-based cuticle molting cycle; and regulation of nematode larval development. Located in trans-Golgi network. Is expressed in head neurons and hypodermis. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human TPST1 (tyrosylprotein sulfotransferase 1) and TPST2 (tyrosylprotein sulfotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tpst-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (12652346..12662286, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Transcription initiation factor IIA subunit 2 Neighboring gene HUN domain-containing protein;Hpc2-related domain-containing protein Neighboring gene ncRNA Neighboring gene TAFII55 protein conserved region domain-containing protein Neighboring gene Elongator complex protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tyrosylprotein sulfotransferase regulates collagen secretion in Caenorhabditis elegans. Kim TH, et al. Mol Cells, 2010 Apr. PMID 20229090
    2. Requirement of tyrosylprotein sulfotransferase-A for proper cuticle formation in the nematode C. elegans. Kim TH, et al. FEBS Lett, 2005 Jan 3. PMID 15620690
    3. Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2. Beisswanger R, et al. Proc Natl Acad Sci U S A, 1998 Sep 15. PMID 9736702, Free PMC Article
    4. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. Ouyang YB, et al. J Biol Chem, 1998 Sep 18. PMID 9733778
    5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data confirmed that worm TPST-1 is localized to the trans-Golgi network (TGN).
      Title: Tyrosylprotein sulfotransferase regulates collagen secretion in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein-tyrosine sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-tyrosine sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-tyrosine sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine sulfation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein-tyrosine sulfotransferase A
    NP_499646.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12652346..12662286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067245.6 → NP_499646.3  Protein-tyrosine sulfotransferase A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499646.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77081, Q9NEW9
      Conserved Domains (1) summary
      pfam13469
      Location:70 → 257
      Sulfotransfer_3; Sulfotransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77081.1

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