php-3 Homeobox protein php-3 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: php-3
Official Full Name: Homeobox protein php-3
Primary source: WormBase:WBGene00004024
Locus tag: CELE_Y75B8A.1
See related: AllianceGenome:WB:WBGene00004024
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of nematode male tail tip morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including coelomocyte; head neurons; intestine; somatic nervous system; and tail neurons. Human ortholog(s) of this gene implicated in congenital vertical talus. Orthologous to several human genes including HOXC10 (homeobox C10). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info